Taurolidine

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Taurolidine ([bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane) is a drug with antimicrobial and anti-lipopolysaccharide properties. Derived from the amino acid taurine, its immunue modulatory action is reported to be mediated with priming and activation of macrophages and polymorphonuclear leukocytes.[1]

Taurolidine has been used to treat patients with peritonitis and as an antiendoxic agent in patients with Systemic inflammatory response syndrome.[2] Additionally, taurolidine demonstrates some anti-tumor properties, with positive results seen in early-stage clinical investigations using the drug to treat gastrointestinal malignancies and tumors of the central nervous system.[2]

Taurolidine has been investigated for the prevention of central venous catheter-related infections; while there is positive in vivo and in vitro evidence supporting such an application, the current evidence is "insufficient to warrant routine use of taurolidine".[3]

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