Taurolidine ([bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane) is a drug with antimicrobial and anti-lipopolysaccharide properties. Derived from the amino acid taurine, its immunue modulatory action is reported to be mediated with priming and activation of macrophages and polymorphonuclear leukocytes.
Taurolidine has been used to treat patients with peritonitis and as an antiendoxic agent in patients with Systemic inflammatory response syndrome. Additionally, taurolidine demonstrates some anti-tumor properties, with positive results seen in early-stage clinical investigations using the drug to treat gastrointestinal malignancies and tumors of the central nervous system.
Taurolidine has been investigated for the prevention of central venous catheter-related infections; while there is positive in vivo and in vitro evidence supporting such an application, the current evidence is "insufficient to warrant routine use of taurolidine".
- ↑ Watson RW, Redmond HP, Mc Carthy J, Bouchier-Hayes D (September 1995). "Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine". J. Leukoc. Biol. 58 (3): 299–306. PMID 7665985. http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=PubMed&issn=0741-5400&title=J%20Leukoc%20Biol&volume=58&issue=3&spage=299&atitle=Taurolidine,%20an%20antilipopolysaccharide%20agent,%20has%20immunoregulatory%20properties%20that%20are%20mediated%20by%20the%20amino%20acid%20taurine.&aulast=Watson&date=1995.
- ↑ 2.0 2.1 Jacobi CA, Menenakos C, Braumann C (October 2005). "Taurolidine--a new drug with anti-tumor and anti-angiogenic effects". Anticancer Drugs 16 (9): 917–21. PMID 16162968. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0959-4973&volume=16&issue=9&spage=917.
- ↑ Bradshaw JH, Puntis JW (August 2008). "Taurolidine and catheter-related bloodstream infection: a systematic review of the literature". J. Pediatr. Gastroenterol. Nutr. 47 (2): 179–86. doi:10.1097/MPG.0b013e318162c428. PMID 18664870. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00005176-200808000-00011.