ProSavin

ProSavin is an experimental drug believed to be of use in the treatment of Parkinson's Disease. It is administered to the striatum in the brain, inducing production of dopamine.[1]

It is manufactured by Oxford BioMedica, who plan to start European Phase I and Phase II clinical trials in 2007. Animal trials have been a success, with dopamine levels restored without the side effects associated with other current treatments for Parkinson's,[2] in particular, without the jerky involuntary movements associated with current drugs.[3]

Mechanism of Action

Prosavin uses Oxford BioMedica's Lentivector delivery system to transfer three genes, aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to secrete dopamine.[4]

See also

References

  1. Oxford BioMedica. Drug Information Page. Retrieved on March 29, 2007.
  2. Daily Telegraph. Investor Information. Retrieved on March 29, 2007.
  3. Ben Hirschler (2009-10-14). "Long-term monkey tests back Oxford's gene therapy". Reuters. http://www.reuters.com/article/scienceNews/idUSTRE59D4DL20091014. Retrieved 2009-10-14. 
  4. Oxford BioMedica . Drug Advanced Information Page. Retrieved on April 5, 2007.
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