Nodular sclerosis

Nodular sclerosis
Classification and external resources
ICD-10 C81.1
ICD-9 201.5
ICD-O: M9663/3-9667/3
GeneReviews 2=

Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma[1] that is the most common subtype of HL in developed countries. It usually affects females more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.

The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment. [2]


  1. Falchi L, Capello D, Palumbo B, et al. (November 2007). [Expression error: Missing operand for > "A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy"]. Eur. J. Haematol. 79 (5): 455–61. doi:10.1111/j.1600-0609.2007.00952.x. PMID 17908180. 
  2. Mauch, Peter; James Armitage, Volker Diehl, Richard Hoppe, Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. p. 107. ISBN 0-7817-1502-4. 

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