Nodular lymphocyte predominant Hodgkin's lymphoma
It is no longer classified as a form of classic Hodgkin's lymphoma (HL). This is because the Reed-Sternberg Cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma.
There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20.
- ↑ Renné C, Martín-Subero JI, Hansmann ML, Siebert R (August 2005). "Molecular cytogenetic analyses of immunoglobulin loci in nodular lymphocyte predominant Hodgkin's lymphoma reveal a recurrent IGH-BCL6 juxtaposition". J Mol Diagn 7 (3): 352–6. PMID 16049307. PMC 1867541. http://jmd.amjpathol.org/cgi/pmidlookup?view=long&pmid=16049307.
- ↑ Achten R, Verhoef G, De Wolf-Peeters C (December 2003). "The importance of follow-up biopsies of clinically suspicious lymphadenopathy in nodular lymphocyte predominant Hodgkin's lymphoma". Haematologica 88 (12): 1431–2. PMID 14688002. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=14688002.
- ↑ Wlodarska I, Stul M, De Wolf-Peeters C, Hagemeijer A (August 2004). "Heterogeneity of BCL6 rearrangements in nodular lymphocyte predominant Hodgkin's lymphoma". Haematologica 89 (8): 965–72. PMID 15339680. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=15339680.
- ↑ Wlodarska I, Nooyen P, Maes B, et al. (January 2003). "Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma". Blood 101 (2): 706–10. doi:10.1182/blood-2002-05-1592. PMID 12393409. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12393409.