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Nemifitide is an experimental, unapproved drug which has been studied for efficacy as an antidepressant in animal testing
and Phase 2 clinical trails.
Chemically unrelated to existing approved antidepressants, nemifitide has a molecular structure similar to melanocyte-inhibiting factor.page 303
Nemifitide has been shown to exhibit activity as an antagonist at the 5-HT2A serotonin receptor subtype, because it prevents the development of fever ordinarily induced by administration of 2,5-Dimethoxy-4-iodoamphetamine. It is believed that the compound's effectiveness as an antidepressant is mediated, at least in part, via serotonergic mechanisms.page 307
- ↑ 1.0 1.1 1.2 Overstreet DH, Hlavka J, Feighner JP, Nicolau G, Freed JS (September 2004). [Expression error: Missing operand for > "Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression"]. Psychopharmacology 175 (3): 303–9. doi:10.1007/s00213-004-1815-9. PMID 14985919.
- ↑