Metanx is a prescription medication made by Pamlab that contains L-methylfolate, methylcobalamin and pyridoxal 5'-phosphate. It is indicated for the treatment of endothelial dysfunction and hyperhomocysteinemia. In particular it has been shown to be an effective treatment for diabetic peripheral neuropathy[1][2] and lower extremity ulcerations such as diabetic foot ulcers.[3]

Metanx contains the following active ingredients (per tablet):

  • L-methylfolate (Metafolin): 2.8 mg
  • Pyridoxal 5'-phosphate: 25 mg
  • Methylcobalamin: 2 mg


  1. Vascular Disease Management 2005;2 (Suppl 6):1S-9S.
  2. Yaqub, Basim A, et al. Effects of methylcobalamin on diabetic neuropathy. Clinical Neurology and Neurosurgery 1992;94:105-111.
  3. Boykin JV, Baylis C. Homocysteine--A Stealth Mediator of Impaired Wound Healing: A Preliminary Study. Wounds 2006;18(4):101-116.

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