Cutaneous T-cell lymphoma

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Cutaneous T cell lymphoma
Classification and external resources
ICD-10 C84.0, C84.1
ICD-9 202.1, 202.2
ICD-O: M9700/3, M9701/3
DiseasesDB 8595
eMedicine med/3486
MeSH D016410
GeneReviews 2=
Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body initially migrate to the skin, causing various lesions to appear. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash which can be very itchy and eventually forming plaques and tumors before metastasizing to other parts of the body.

Contents

Classification

Cutaneous T-cell lymphomas may be divided into the following types:<ref name="Andrews">James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. </ref>:727–740

Treatment

There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.

FDA approved treatments are :<ref>http://www.istockanalyst.com/article/viewnewspaged/articleid/3622028/pageid/1</ref>

Other (off label) Treatments include:

Other drugs are under investigation (for example panobinostat).

Epidemiology

Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas.<ref name="isbn0-7817-5007-5">Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 283. ISBN 0-7817-5007-5. "Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)" </ref>

There is some evidence of a relationship with human T-lymphotropic virus.<ref name="pmid15726602">Nicot C (March 2005). [Expression error: Missing operand for > "Current views in HTLV-I-associated adult T-cell leukemia/lymphoma"]. Am. J. Hematol. 78 (3): 232–9. doi:10.1002/ajh.20307. PMID 15726602. </ref>


See also

References

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External links

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