Calcium carbimide

Calcium carbimide
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Systematic (IUPAC) name
calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
Identifiers
CAS number 8013-88-5
ATC code N07BB02
PubChem CID 6335910
Chemical data
Formula C6H8O7.CH2N2.Ca
Mol. mass 288.268 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status  ?

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

A recent 9-year study found that incorporation of supervised carbimide and the similar drug, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.[1]

References

  1. Krampe H, Stawicki S, Wagner T, et al. (January 2006). [Expression error: Missing operand for > "Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome"]. Alcoholism, clinical and experimental research 30 (1): 86–95. doi:10.1111/j.1530-0277.2006.00013.x. ISSN 0145-6008. PMID 16433735. 


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